The 49ers will rest a few starters, and a number of injured players will also sit out the preseason finale in Houston.
16 players will not play for San Francisco in their final preseason game.
Unsurprisingly, quarterback Jimmy Garoppolo is among the 16.
Kinlaw returned from reconstructive ACL surgery last year, so the 49ers have taken it slowly.
He was heavily involved in the team's win over the Vikings on Aug. 20, so it stands to reason that he wouldn't be rushed back into action five days later.
It's also no surprise that Williams and Bosa aren't in the lineup.
The left tackle and defensive end are two of the best players in the game. They don't require a risky preseason tune-up.
Armstead has returned to practise after missing the majority of training camp due to a strained MCL.
The condition of McGlinchey is also uncertain, but head coach Kyle Shanahan believes the former first-round pick should be able to play in the season opener.
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