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Researchers have constructed the first-ever molecular atlas of the human brain vasculature at single-cell resolution.
The study involved teams from top institutions like UHN, University of Zurich, and Weill Cornell Medicine.
Endothelial cells, which line blood vessels, show different behaviors across brain development stages.
The brain's vasculature is crucial for its proper functioning from early development to adulthood and during diseases.
Over 600,000 cells from 117 samples were sequenced, offering an in-depth look into brain vasculature.
In a healthy brain, vascular growth stops in adulthood, but tumors and malformations can reactivate this growth.
The study found that the brain's vasculature differs significantly from other organs, especially during disease.
Insights from this research could lead to therapies that inhibit abnormal vascular growth and boost the immune response.
This atlas will benefit researchers in fields ranging from developmental biology to immunology, opening new avenues for understanding and treating brain diseases.